@article { author = {Samir, Amr and Nabil, Fedaa and Ashour, Mahmoud and sharafeddin, Mahmoud and Mahdy, Abdrahman}, title = {Impact of chronic liver disease on COVID-9 infection at Zagazig University Hospitals}, journal = {African Journal of Gastroenterology and Hepatology}, volume = {5}, number = {2}, pages = {16-31}, year = {2022}, publisher = {Scientific Society of Kafr El-Sheikh Doctors}, issn = {2735-5489}, eissn = {2735-5497}, doi = {10.21608/ajgh.2022.176239.1020}, abstract = {Background. Chronic liver disease (CLD) is linked to immune system failure, which increases the risk of infections and consequences brought on by COVID-19. Therefore, we aimed to compare hospitalized COVID -19 patients with and without CLD to assess the effect of CLD on the severity of COVID-19 infection. Methods. The study was conducted between April and October 2022 at Zagazig university hospitals. It enrolled 108 subjects admitted at the isolation hospital for COVID-19 illness. The cases were allocated equally into three groups, group (I): Patients without evidence of liver disease. Group (II): patients with chronic hepatitis, and group (III): patients with cirrhotic liver. Result. There were significant correlations between the severity of COVID -19 and the CTP classification of Group III (r=0.5 p=0.05 in child A, r=0.08 p=0.05 in child B, r=0.4 p=0.001in child C). In addition, there were significant correlations between laboratory parameters such as INR (r=0.6, p=0.05), bilirubin (r=0.4, p=0.001), ALT (r= 0.5, p=0.05), and AST (r=0.08, p=0.05) and severity of COVID -19 in studies groups. Conclusion: Those with CLD and cirrhosis had a higher death rate. COVID-19 severity related to the Child-Turcotte-Pugh score (CTP) score.}, keywords = {COVID-19,Chronic liver disease,Child-Turcotte-Pugh,Zagazig}, url = {https://ajgh.journals.ekb.eg/article_275455.html}, eprint = {https://ajgh.journals.ekb.eg/article_275455_a401f8c8e3c9cdd8862fcb5f4b5db4b7.pdf} }