EVALUATION OF PLATELET INDICES IN EGYPTIAN CIRRHOTIC PATIENTS

Document Type : Scientific Research

Authors

1 Clinical Pathology Department, Faculty of Medicine, Alexandria University, Egypt.

2 Tropical medicine department.Alexandria university.

3 Internal Medicine Department (hematology unit), Faculty of Medicine, Alexandria University, Egypt.

4 Internal medicine department.GIT unit, faculty of medicine.Alexandria University.

5 Medical Laboratory Technology Department, Faculty of Applied Health Sciences Technology, Pharos University, Alexandria, Egypt.

Abstract

Background:
Liver cirrhosis is an essential public health concern in Egypt. Platelet indices (PIs) are parameters routinely obtained as a part of a complete blood count. They are evolving as novel biomarkers of diagnostic and prognostic significance in hepatic disorders. Aim: A prospective study was planned to detect the diagnostic and prognostic potentials of Platelet indices (PIs) in cirrhotic individuals and hepatocellular carcinoma patients. Materials and Methods: 250 subjects participated in the study. Among them, 200 were diagnosed with liver cirrhosis and further classified into four groups: Groups I, II, and III: Each consists of 50 patients (Child-Pugh A, B, C) respectively, Group IV: 50 patients with hepatocellular carcinoma (HCC) and 50 healthy subjects as control Group V. Detection of PIs was done by Sysmex XT-1800i automated hematology analyzer.
Results: The mean platelet volume (MPV)value is positively correlated with INR and plasma bilirubin and negatively correlated with plasma albumin in all three groups of cirrhotic individuals without HCC.MPV showed a significant elevation in cases with more severe liver disease based on MELD and Child scores. MPV in HCC patients was positively related to tumor size, Child score, BCLC, and PV thrombosis but had no statistical significance. Plateletcrit (PCT) exhibited significant differences between different cirrhotic Child groups. Platelet distribution width (PDW) levels were significantly elevated in patients compared to healthy subjects, yet there was a non-significant difference in its value among patients.
Conclusions: Platelet indices might be utilized as progression and risk stratification markers in cirrhotic individuals.

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Bassam Mansour Salama (Assistant professor of tropical medicine), Amany Mohammed (Assistant professor of community medicine, biostatistician), and Mohamed Hassan Ali Emara (professor of gastroenterology, hepatology, and infectious diseases) were the peer reviewers. E- Editor: Salem Youssef Mohamed, Osama Ahmed Khalil, Amany Mohammed. Copyright ©. This open-access article is distributed under the Creative Commons Attribution License (CC BY). The use, distribution, or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited. The original publication in this journal is cited by accepted academic practice. Disclaimer: The authors' claims in this article are solely their own and do not necessarily represent their affiliated organizations or those of the publisher, the editors, and the reviewers. Any product evaluated in this article or its manufacturer's claim is not guaranteed or endorsed by the publisher. Ethics Approval and Consent to Participate: The Institutional Review Board Committee at Alexandria University approved the experimental protocol. Consent for publication: All patients included in this research gave written informed permission to publish the data contained within this study. Data and materials availability: The datasets used or analyzed during the current study are available from the corresponding author upon reasonable request. Competing interests: The authors declare that they have no competing interests. Funding: This study had no funding from any resource. Authors’ contributions Asmaa M. Gouda and Mohamed A. Abdelaziz were responsible for conception and revision. Mayada Aly Mousa, Hussein M. Saad, and Nesrine A. Helaly were responsible for interpreting and analyzing data. Asmaa M. Gouda and Mohamed A. Abdelaziz wrote the manuscript, which was revised and approved by all co-authors. Acknowledgments: The authors are thankful for the patients and all members who helped in this research.

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