Gastric signet ring cell adenocarcinoma associated with Menetrier’s disease: a rare North African female case report

Document Type : Case Reports

Authors

1 Department of Pathology, Sidi Bel Abbes University Hospital. Faculty of Medicine, Djilali Liabes University, Algeria.

2 Laboratory of genetic diagnosis and microscopy platform, Biotechnology and Health Division, National Biotechnology Research Center, Constantine, Algeria.

Abstract

Background
 Menetrier's disease is an uncommon disease characterized by diffuse hypertrophy of gastric mucosa and giant gastric rugae with an increased risk of gastric cancer. Only a few reports supporting its association with gastric cancer have been found.
Material and methods
We present the case of signet ring cell adenocarcinoma associated with Menetrier's disease. The patient is a 54-year-old Algerian female.
Results
A 54-year-old woman was admitted to our hospital with a history of anemia, anorexia, and 10 kg weight loss. During her hospitalization, the patient presented an extradural hematoma. A biopsy was performed, which revealed a bone metastasis of the carcinomatous process. Abdominal computed tomography demonstrated diffuse thickening of the gastric wall. A gastric biopsy specimen showed thickened gastric mucosa and cystic dilatation of glands compatible with Menetrier's disease and diffuse infiltration by signet ring cell adenocarcinoma. A total gastrectomy was performed.
Conclusion
A patient with signet ring cell adenocarcinoma associated with Menetrier's disease is reported in our case study.

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Main Subjects

Footnotes. Ahmed Elagrodey (Assistant professor of internal medicine) and Hayam Rashed (professor of pathology) were the peer reviewers. E- Editor: Salem Youssef Mohamed, Osama Ahmed Khalil, Amany Mohammed. Copyright ©. This open-access article is distributed under the Creative Commons Attribution License (CC BY). It may be used, distributed, or reproduced in other forums, provided the original author(s) and the copyright owner(s) are credited. The original publication in this journal must be cited according to accepted academic practice. Disclaimer: The authors' claims in this article are solely their own and do not necessarily represent their affiliated organizations or those of the publisher, the editors, and the reviewers. Any product evaluated in this article or its manufacturer's claim is not guaranteed or endorsed by the publisher. Ethics Approval and Consent to Participate: The Institutional Review Board Committee approved the experimental protocol. Consent for publication: the patient in this research gave written informed permission to publish the data in this study. Data and materials availability: The datasets used or analyzed during the current study are available from the corresponding author upon reasonable request. Competing interests: The authors declare that they have no competing interests. Funding: This study had no funding from any resource. Authors' contributions, Houria Belkralladi and Zakaria Merad, were responsible for conception and revision. Feriel Sellam and Abdelnacer Tou were responsible for interpreting and analyzing data. Houria Belkralladi, Zakaria Merad, and Feriel Sellam wrote the manuscript, which was revised and approved by all co-authors. Acknowledgments: The authors would like to thank the members of the pathology department of Sidi Bel Abbes Hospital for their invaluable support, guidance, and educational insight. This work was done according to the CARE guidelines. Ethical approval: All procedures involving human participants followed the institutional and national research committee's moral standards, the 1964 Helsinki Declaration, and its later amendments or comparable ethical standards. All authors declare that consent was obtained from the patient (or other approved parties) to publish this case report and accompanying images.

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