GASTROINTESTINAL STROMAL TUMORS: ABOUT 4 CASES AT THE ANGRE UNIVERSITY HOSPITAL (CÖTE D’IVOIRE)

Document Type : Case Reports

Authors

1 Hepatogastroenterology Unit, University Hospital of Angré, Félix Houphouët-Boigny University, Abidjan, Côte d’Ivoire

2 Félix Houphouët-Boigny University, Abidjan, Côte d’Ivoire

3 Angré University Hospital

4 Angre University Hospital

Abstract

Background
Gastrointestinal stromal tumors are rare, sporadic connective tissue tumors. Very few cases have been reported in Africa, including Ivory Coast.
Aim
To report 4 cases of GIST at the Angré University Hospital in Ivory Coast.
Patients and method
It was a retrospective case series from April 2, 2020, to May 31, 2023, at the Hepato-gastroenterology Unit of the Angré University Hospital. GIST cases followed in consultation or hospitalization, confirmed by pathological examination and immunohistochemistry, were included. Data collection was based on consultation and hospitalization files, entered and processed anonymously. The variables studied were sociodemographic, clinical, paraclinical, and therapeutic data.
Results
We reported four cases of GIST. The patients had an average age of 61.7 years with a sex ratio of 1. The circumstances of discovery were a digestive hemorrhage, an epigastric mass, epigastric pain, and anorexia. The most common area was the stomach (3), and there was 1 case of mesentery GIST. Immunohistochemistry found three moderate to intense cytoplasmic and membrane markings by the anti-CD117 antibody, four markings for the anti-DOG1 antibody, three markings by the anti-CD34 antibody, and two membrane markings of the endothelial cell by the antibody anti-CD31. Treatment was surgical in 2 patients, followed by adjuvant treatment with Imatinib. The other two patients were treated with Imatinib alone for one and as neoadjuvant for the other, which will be followed by surgery if the tumor size regressed.
Conclusion
Gastrointestinal stromal tumors are rare pathologies with non-specific symptoms. For optimal management, the diagnosis must be confirmed by immunohistochemistry.

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Footnotes. Ahmed Fathy (Assistant professor of internal medicine), Hayam Rashed (professor of pathology), Mohamed Emara (Professor of gastroenterology, hepatology, and infectious diseases), and Sara Salem (lecturer of internal medicine, gastroenterology, and hepatology unit) were the peer reviewers. E- Editor: Salem Youssef Mohamed, Osama Ahmed Khalil, Amany Mohammed. Copyright ©. This open-access article is distributed under the Creative Commons Attribution License (CC BY). It may be used, distributed, or reproduced in other forums, provided the original author(s) and the copyright owner(s) are credited. The original publication in this journal must be cited according to accepted academic practice. Disclaimer: The authors' claims in this article are solely their own and do not necessarily represent their affiliated organizations or those of the publisher, the editors, and the reviewers. Any product evaluated in this article or its manufacturer's claim is not guaranteed or endorsed by the publisher. Ethics Approval and Consent to Participate: The Institutional Review Board Committee approved the experimental protocol. Consent for publication: the patients in this research gave written informed permission to publish the data in this study. Data and materials availability: The datasets used or analyzed during the current study are available from the corresponding author upon reasonable request. Competing interests: The authors declare that they have no competing interests. Funding: This study had no funding from any resource. Authors’ contributions Henriette Ya Kissi Anzouan-Kacou, Adjéka Stanislas Doffou were responsible for conception and revision. Aboubacar Demba Bangoura, Abdoulatif Yaogo, and Amoin Ange Christelle DegnonTou interpreted and analyzed data. Innocents Boa Brou and Alain Koffi Attia wrote the manuscript, which was revised and approved by all co-authors. Acknowledgments: The authors would like to thank the members of the pathology department of Sidi Bel Abbes Hospital for their invaluable support, guidance, and educational insight. This work was done according to the CARE guidelines. Ethical approval: All procedures involving human participants followed the institutional and national research committee's moral standards, the 1964 Helsinki Declaration, and its later amendments or comparable ethical standards. All authors declare that consent was obtained from the patient (or other approved parties) to publish this case report and accompanying images.

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