Helicobacter pylori infection as a risk factor for changes in some hematological and biochemical parameters among Egyptian population

Document Type : Original Clinical

Authors

1 Lecturer at the Tropical Medicine Department, Alexandria Faculty of Medicine.

2 Damanhour Fever Hospital.

3 Professor of tropical medicine, Alexandria University, Egypt.

4 Professor of clinical pathology, Alexandria University, Egypt.

Abstract

Background: Helicobacter pylori can be an etiology of chronic gastritis, peptic ulcer, and stomach cancer. The aim was to evaluate the relationship between H. pylori infection and alterations in some hematological and biochemical parameters among the Egyptian people. Method: Ninety individuals with confirmed H. pylori infection by the fecal antigen were selected and then followed after a month of treatment with Levofloxacin, amoxicillin, and a proton pump inhibitor; they underwent testing again for hematological and biochemical parameters after treatment of H.pylori. Results: both groups, group A (Before treatment) and Group B (After 1 month of therapy), showed a statistically significant relation between the presence of H. pylori and the CBC values; patients with pre-existing dyslipidemia exhibited a link between H. pylori infection and reduced levels of HDL-C as well as elevated LDL-C and triglycerides. Conclusion: H. pylori is associated with changes in some hematological and biochemical parameters. 

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Mohamed Emara (Professor of gastroenterology, hepatology, and infectious diseases), Marwa Shabana (Assistant professor of clinical pathology), and Amany Mohamed (Assistant professor of family medicine) were the peer reviewers. E- Editor: Salem Youssef Mohamed, Osama Ahmed Khalil, Amany Mohammed. Copyright ©. This open-access article is distributed under the Creative Commons Attribution License (CC BY). It may be used, distributed, or reproduced in other forums, provided the original author(s) and the copyright owner(s) are credited. The original publication in this journal must be cited according to accepted academic practice. Disclaimer: The authors' claims in this article are solely their own and do not necessarily represent their affiliated organizations or those of the publisher, the editors, and the reviewers. Any product evaluated in this article or its manufacturer's claim is not guaranteed or endorsed by the publisher. Ethical approval: Written informed consent was obtained from the patient after the studies were well explained before data collection. The hospital's Research Ethics Review Committee approved the study. In April, the Ethics Committee of the Faculty of Medicine at Alexandria University accepted the current research, with the serial number 0305083. Study protocol: In adherence to the principles outlined in the Helsinki Declaration, the study protocol was implemented with approval from the institutional review board. Before commencing the research, written consent was obtained from the patient to utilize their clinical information. Data and materials availability: The datasets used or analyzed during the current study are available from the corresponding author upon reasonable request. Competing interests: The authors declare that they have no competing interests. Funding: This study had no funding from any resource. This work was done according to the STROBE guidelines. Authors' contributions Mohamed Gamal Abdrabou and Emad Rashad Badr collected and followed up on the patients, carrying out the requested investigations. Hosam Eldin Abouelkheir and Abeer Elhadidi followed up with the patients and analyzed the collected data. All authors authorized the manuscript. Acknowledgment: none.

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