The Potential Role of Platelet Indices and Red Cell Distribution Width in Metabolic Dysfunction-Associated Fatty Liver Disease

Document Type : Original Clinical

Authors

1 Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, Egypt.

2 Department of Public Health and Community Medicine, Faculty of Medicine, Menoufia University, Egypt.

3 Department of Internal Medicine and Nephrology, Faculty of Medicine, Tanta University, Egypt.

Abstract

Background:
Hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and even hepatocellular carcinoma are all possible outcomes of metabolic dysfunction-associated fatty liver disease (MAFLD). Some platelet function measures are strongly correlated with the incidence of insulin resistance's intensity and its associated problems. Platelet indices, including platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), red cell distribution width (RDW), and red cell distribution width to platelet ratio (RPR), were found to be associated with the presence of many diseases. Hence, this research aimed to evaluate the significance of platelet indices and RDW in MAFLD and their possible association with the degree of liver steatosis and fibrosis.
Patients and methods:
This study was carried out on 220 patients who attended Tanta Tropical Medicine and fulfilled MAFLD criteria and CBC, including PC, MPV, PDW, PCT, RDW, and RPR, determined in all patients.
Results:
It was found that the PC was significantly decreased as the steatosis grade increased (p <0.00). There was a significant increase in MPV as the steatosis grade increased (p <0.001). PDW% also substantially increased as the steatosis grade increased (p <0.001). It also found that RDW% showed a significant increase when the steatosis grade increased (p<0.001), while PCT% showed no significant difference in its level about the steatosis grades, p= 0.917.
Conclusion: MPV, PDW, RDW, and RPR may be used as non-invasive indicators for liver fibrosis and steatosis in MAFLD.

Keywords

Footnotes. Peer-Reviewers: Sara salem (lecturer of internal medicine), Marwa Shabana (Assistant professor of clinical pathology), Ola Elfarargey (professor of medical oncology). E- Editor: Salem Youssef Mohamed, Osama Ahmed Khalil, Mohamed Hassan Ali Emara. Copyright ©. This open-access article is distributed under the Creative Commons Attribution License (CC BY). The use, distribution, or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited. The original publication in this journal is cited by accepted academic practice. No use, distribution, or reproduction is permitted, complying with these terms. Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent their affiliated organizations or those of the publisher, the editors, and the reviewers. Any product evaluated in this article or its manufacturer's claim is not guaranteed or endorsed by the publisher. Ethics Approval and Consent to Participate: All procedures followed were by the ethical standards of the responsible committee on human experimentation (Institutional Review Board (IRB)" (34908/ 9 /21) of Tanta University and with the Helsinki Declaration of 1964 and later versions. Consent for publication: All patients included in this research gave written informed permission to publish the data contained within this study. Availability of data and materials: The datasets used or analyzed during the current study are available from the corresponding author upon reasonable request. Competing interests: The authors declare that they have no competing interests. Funding: This study had no funding from any resource. Authors' contributions The study was conceptualized and designed by all authors. SM, RB, and SS collected and compiled data. SM and RB conducted the statistical analysis, while RB and SS drafted the manuscript. SM, RB, and SS provided significant intellectual input throughout the project, contributing to comments and revisions. All authors reviewed and approved the final manuscript.

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