Helicobacter Pylori Infection, Lipid Profile, and Insulin Resistance in Obese Patients with Non-Alcoholic Fatty Liver Disease

Document Type : Original Clinical

Authors

1 Faculty of medicine,Tanta University

2 Lecturer of Internal Medicine, Internal Medicine Department, Faculty of Medicine, Tanta University, Egypt

3 Clinical Pathology Department, Faculty of Medicine, Tanta University, Egypt

4 Professor of Internal Medicine, Internal Medicine Department, Faculty of Medicine, Tanta University, Egypt

Abstract

Aim: Nonalcoholic fatty liver disease (NAFLD) is characterized by the presence of hepatic steatosis without any secondary causes contributing to the accumulation of fat in the liver. The influence of gut microbiota, including Helicobacter pylori (H. pylori), on liver injury has not been thoroughly investigated.
Methods: This cross-sectional case-control study involved sixty patients with NAFLD (group 1) and sixty healthy individuals of matched age and sex as the control group (group 2). NAFLD patients were diagnosed by ultrasound, aged≥ 18 years old, and body mass index (BMI) ≥ 30 kg/m2. Investigations included fasting insulin level, fasting blood glucose (FBG), cholesterol, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), liver profile, H. pylori antigen in stools, H. pylori IgG antibodies (IgG Abs) and homeostatic model assessment for insulin resistance (HOMA-IR).
Results: Group 1 had significantly higher systolic and diastolic blood pressures (p < 0.001 and 0.015, respectively). Additionally, the NAFLD group exhibited significantly elevated levels of FBG (p = 0.004), HbA1c (p < 0.001), cholesterol (p = 0.007), LDL-C (p = 0.001), alanine transferase (ALT) (p < 0.001), and aspartate transferase (AST) (p: 0.025). Furthermore, the NAFLD group had a significantly higher number of patients with positive H. pylori antibodies (p < 0.001), although the antibody titers were not statistically different between the two groups (p:  0.516).
Conclusion: Obese patients with NAFLD had a significantly higher number of patients with positive H. pylori antibodies and showed increased insulin resistance and dyslipidemia compared to the control group.

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Footnotes. Ahmed Fathy (Assistant professor of internal medicine, gastroenterology, and hepatology unit) and Sara Salem (lecturer of internal medicine, gastroenterology, and hepatology unit) were the peer reviewers. E- Editor: Salem Youssef Mohamed, Osama Ahmed Khalil, Amany Mohammed. Copyright ©. This open-access article is distributed under the Creative Commons Attribution License (CC BY). It may be used, distributed, or reproduced in other forums, provided the original author(s) and the copyright owner(s) are credited. The original publication in this journal must be cited according to accepted academic practice. Disclaimer: The authors' claims in this article are solely their own and do not necessarily represent their affiliated organizations or those of the publisher, the editors, and the reviewers. Any product evaluated in this article or its manufacturer's claim is not guaranteed or endorsed by the publisher. Ethical considerations Each patient's file was assigned a unique code number containing all investigations, ensuring the privacy of patient data. Before study inclusion, all subjects had written informed consent. The local ethics commission approved the study (approval code: 33913/6/29). Consent for publication: the patients in this research gave written informed permission to publish the data in this study. Ethical approval: All procedures involving human participants followed the institutional and national research committee's moral standards, the 1964 Helsinki Declaration, and its later amendments or comparable ethical standards. All authors declare that consent was obtained from the patient (or other approved parties) to publish this study. Data and materials availability: The datasets used or analyzed during the current study are available from the corresponding author upon reasonable request. Competing interests: The authors declare that they have no competing interests. Funding: This study had no funding from any resource. This work was done according to the STROBE guidelines. Authors’ contributions All listed authors have contributed substantially, directly, and intellectually to the work and have approved its publication.

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