Evaluation of Response to Treatment of Helicobacter Pylori Infection in Portal Hypertensive HCV Cirrhotic Patients

Document Type : Original Clinical

Authors

1 Lecturer at the Tropical Medicine Department, Alexandria Faculty of Medicine.

2 Internal Medicine Department.GIT unit, Faculty of Medicine.Alexandria University.

3 Department of Medical Education, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

4 Medical Microbiology and Immunology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Abstract

Background: Helicobacter pylori is an etiology of various gastrointestinal disorders such as chronic gastritis, peptic ulcer, and stomach cancer. Aim: The aim was to assess the response to Helicobacter pylori treatment in patients with portal hypertensive hepatitis C virus (HCV)   cirrhosis. Methods: two groups; Group A (case group): 52 H. pylori-positive HCV portal hypertensive cirrhotic cases. Group B (control group): 52 H. pylori-positive non-portal hypertensive, non-cirrhotic individuals. Both groups were given levofloxacin-based therapy (Levofloxacin 500 mg / Amoxicillin 1 g bid/ Pantoprazole 40 mg bid) for 2 weeks. The H. pylori stool antigen test was repeated 4 weeks after treatment. Results: A statistically significant difference was obtained regarding H. pylori antigen testing before and after treatment in the control group compared to the case group. Conclusion: H. pylori infection is associated with a better treatment response in non-cirrhotic, non-portal hypertensive patients compared to those with HCV-cirrhosis and portal hypertension. 

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Ahmed Fathy (Professor of internal medicine, gastroenterology, and hepatology unit), Mohamed Emara (Professor of gastroenterology, hepatology, and infectious diseases department), and Amany Mohamed (Professor of family medicine and biostatistician) were peer reviewers. E- Editor: Salem Youssef Mohamed, Osama Ahmed Khalil, Amany Mohammed. Copyright ©. This open-access article is distributed under the Creative Commons Attribution License (CC BY). It may be used, distributed, or reproduced in other forums, provided the original author(s) and the copyright owner(s) are credited. The original publication in this journal must be cited according to accepted academic practice. Disclaimer: The authors' claims in this article are solely their own and do not necessarily represent their affiliated organizations or those of the publisher, the editors, or the reviewers. Any product evaluated in this article or its manufacturer's claim is not guaranteed or endorsed by the publisher. Ethics approval Informed consents were obtained from all individuals involved in this work. The Ethics Committee of the Faculty of Medicine at Alexandria University approved the current research in February 2023, with serial number 0305999. Data and materials availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. Competing interests: The authors declare that they have no competing interests. Funding: This study had no funding from any source. This work was conducted following the STROBE guidelines. Authors' contributions: All authors made substantial contributions to the study's conception, design, data acquisition, analysis, or interpretation; drafting or revising the article; and final approval of the version to be submitted. Acknowledgments: We would like to express our sincere gratitude to all the supporters of this work, our professors who have always encouraged us, and the patients who participated in our work.