A cross-sectional study clarifying the possible connection Between Irritable Bowel Syndrome and Serum Level of Vitamin D

Document Type : Original Clinical

Authors

1 Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University

2 Physiology Department, Faculty of Medicine, Tanta University

10.21608/ajgh.2025.407297.1088

Abstract

Background and Aim:
Irritable bowel syndrome (IBS) is among the most common chronic functional gastrointestinal disorders, affecting approximately 10%–22% of adults. Vitamin D has been linked to several systemic conditions; however, its exact role in IBS remains unclear. This study aimed to evaluate the possible association between serum vitamin D levels and IBS.
Patients and Methods: A cross-sectional study was conducted on 100 participants divided into two groups: Group I included 50 patients diagnosed with IBS according to the Rome IV criteria. At the same time, Group II consisted of 50 healthy subjects serving as controls. Serum vitamin D levels were measured in both groups.
Results: A statistically significant difference was observed between the two groups in terms of vitamin D levels (p-value = 0.012). Among IBS patients, 19 (38%) had sufficient vitamin D (>30 ng/mL), while 31 (62%) had subnormal levels. In contrast, 34 (68%) of the control group had sufficient levels, and 16 (32%) were deficient.
Conclusions: Vitamin D deficiency may represent a contributing factor in IBS. Therefore, routine assessment of vitamin D levels could be beneficial in patients presenting with IBS.

Keywords

Main Subjects


Sara Salem (lecturer in the internal medicine, gastroenterology, and hepatology unit), Nevin Fouad (Professor in the internal medicine, gastroenterology, and hepatology unit), and Amany Mohamed (Biostatistician and Professor of Family Medicine) were peer reviewers. E- Editor: Salem Youssef Mohamed, Osama Ahmed Khalil, Amany Mohammed. Copyright ©. This open-access article is distributed under the Creative Commons Attribution License (CC BY). It may be used, distributed, or reproduced in other forums, provided the original author(s) and the copyright owner(s) are credited. The original publication in this journal must be cited according to accepted academic practice. Disclaimer: The authors' claims in this article are solely their own and do not necessarily represent their affiliated organizations or those of the publisher, the editors, or the reviewers. Any product evaluated in this article or its manufacturer's claim is not guaranteed or endorsed by the publisher. Ethics approval Written informed consent was obtained from all participants before enrollment. Ethics committee approval was received for this study from the Institutional Review Board of Tanta Faculty of Medicine (approval code: 36264PR349/9/23), in accordance with the provisions of the 1975 Declaration of Helsinki. All patients and/or their legal guardian(s) provided written informed consent before participation in any protocol‑specific procedure. None of the human participants in this study are minors. All methods were carried out in accordance with the guidelines and regulations of the Declaration of Helsinki. Data and materials availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. Competing interests: The authors declare that they have no competing interests. Funding: Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB). This work was conducted in accordance with the STROBE guidelines. Authors' contributions: EH and AE contributed substantially to the conception, design, interpretation of the results, and discussion of this article. FE and NK contributed to the supervised data collection, SE, AA, and SM interpreted the results, and drafted this article. All authors were responsible for writing, reviewing, and editing the manuscript revision. All of the authors have read and approved the final version of this manuscript. Acknowledgments: Not applicable.