1
Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University
2
Physiology Department, Faculty of Medicine, Tanta University
10.21608/ajgh.2025.407297.1088
Abstract
Background and Aim: Irritable bowel syndrome (IBS) is among the most common chronic functional gastrointestinal disorders, affecting approximately 10%–22% of adults. Vitamin D has been linked to several systemic conditions; however, its exact role in IBS remains unclear. This study aimed to evaluate the possible association between serum vitamin D levels and IBS. Patients and Methods: A cross-sectional study was conducted on 100 participants divided into two groups: Group I included 50 patients diagnosed with IBS according to the Rome IV criteria. At the same time, Group II consisted of 50 healthy subjects serving as controls. Serum vitamin D levels were measured in both groups. Results: A statistically significant difference was observed between the two groups in terms of vitamin D levels (p-value = 0.012). Among IBS patients, 19 (38%) had sufficient vitamin D (>30 ng/mL), while 31 (62%) had subnormal levels. In contrast, 34 (68%) of the control group had sufficient levels, and 16 (32%) were deficient. Conclusions: Vitamin D deficiency may represent a contributing factor in IBS. Therefore, routine assessment of vitamin D levels could be beneficial in patients presenting with IBS.
Mansour, S., Elgebaly, F., Khalaf, N., Ebrahim, S., Almedin, A., Elgendy, A., & Habba, E. (2025). A cross-sectional study clarifying the possible connection Between Irritable Bowel Syndrome and Serum Level of Vitamin D. African Journal of Gastroenterology and Hepatology, 8(1), 165-174. doi: 10.21608/ajgh.2025.407297.1088
MLA
Shimaa Mansour; Fatma Elgebaly; Nahla Khalaf; Shimaa Ebrahim; Ahmed Almedin; Aymen Elgendy; Eslam Habba. "A cross-sectional study clarifying the possible connection Between Irritable Bowel Syndrome and Serum Level of Vitamin D", African Journal of Gastroenterology and Hepatology, 8, 1, 2025, 165-174. doi: 10.21608/ajgh.2025.407297.1088
HARVARD
Mansour, S., Elgebaly, F., Khalaf, N., Ebrahim, S., Almedin, A., Elgendy, A., Habba, E. (2025). 'A cross-sectional study clarifying the possible connection Between Irritable Bowel Syndrome and Serum Level of Vitamin D', African Journal of Gastroenterology and Hepatology, 8(1), pp. 165-174. doi: 10.21608/ajgh.2025.407297.1088
VANCOUVER
Mansour, S., Elgebaly, F., Khalaf, N., Ebrahim, S., Almedin, A., Elgendy, A., Habba, E. A cross-sectional study clarifying the possible connection Between Irritable Bowel Syndrome and Serum Level of Vitamin D. African Journal of Gastroenterology and Hepatology, 2025; 8(1): 165-174. doi: 10.21608/ajgh.2025.407297.1088